Professor Onishi Motoko from the Department of Applied Biochemistry, Department of Applied Biology, Chubu University, Japan, and others cooperated with San-ei Sucrochemical, a saccharified product company that produces glucose and other saccharification products, and found through human clinical trials that indigestible oligosaccharides possess both sugar and acid properties. "マルトビオン酸" inhibits the loss of collagen components in bones and helps maintain bone components.
About five years ago, the research team looked at the "maltonic acid" contained in honey, which people have been eating since ancient times, and evaluated its effect on maintaining bone health. In the evaluation experiment, the research team first performed cell experiments using bone marrow cells collected from mouse femurs and found that adding maltonic acid to the cells inhibited osteoclast differentiation. Then, animal experiments were conducted, and after feeding the ovariectomized postmenopausal model mice with a diet containing maltonic acid for 80 consecutive days, it was confirmed that calcium loss and bone density in the femur were significantly suppressed compared with mice fed a diet without maltonic acid. decline.
人体への影響を確認するために、中部大学の40代から60代の女性従業員が1日4gのマルトン酸を含む顆粒を4週間連続で摂取するというヒトの臨床試験も実施されました。 結果は、33人の閉経期の男性の尿中の骨-由来のコラーゲン成分（DPD、u - NTx、骨吸収の指標）の排泄が、それと比較して有意に減少したことを示しました。マルトン酸の摂取前。 、マルトン酸の持続摂取は骨量減少を抑制しました。 さらに、マルトン酸は難消化性オリゴ糖であるため、この臨床試験では、マルトン酸が下剤を改善し、胃腸の状態を調節する効果もあることが確認されました。
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